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KMID : 0043320010240050418
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Archives of Pharmacal Research
2001 Volume.24 No. 5 p.418 ~ p.423
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Constituents of the Essential Oil of the Cinnamomum cassia Stem Bark and the Biological Properties
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Choi Jong-Won
Lee Kyung-Tae
Ka Hyeon
Jung Won-Tae
Jung Hyun-Ju
Park Hee-Juhn
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Abstract
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CC-MS analysis on the essential oil (CC-oil) of Cinnamomum cassia stem bark led to the identification of cinnamaldehyde (CNA, 1), 2-hydroxycinnamaldehyde (2-CNA), coumarin (2), and cinnamyl acetate. The major volatile flavor in CC-oil was found to be 2-CNA. Coumarin was first isolated from this plant by photochemical isolation and spectroscopic analysis. CNA and CC-oil showed potent cytotoxicity, which was effectively prevented by N-acetyl-L-cysteine (NAC) treatment. Intraperitoneal administration with CNA considerably decreased malondialdehyde (MDA) formation and glutathione S-transferase activity in rats. These results suggest that CC-oil and CNA can regulate the triggering of hepatic drugmetabolizing enzymes by the formation of a glutathione-conjugate.
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KEYWORD
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Cinnamomum cassia, Lauraceae, cinnamaldehyde, essential oil, cytotoxicity, glutathione S-transferase
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